Two simple, accurate, economical and reproducible UV Spectrophotometric methods for simultaneous analysis of Terfenadine and Dextromethorphan hydrogen bromide from combined suspension dosage form have been developed. First method was developed making use of fourth order derivative spectroscopy using 274.8 nm and 298.0 nm as zero crossing points for estimation of Terfenadine and Dextromethorphan hydrogen bromide respectively. Second developed method is based on two wavelength calculation; wavelengths selected for estimation of Terfenadine were 220.6 nm and 230.0 nm. Estimation of Dextromethorphan hydrogen bromide was carried out directly at 280.0 nm as Terfenadine has zero absorbance at this wavelength. Solvent used for development of Spectrophotometric methods was methanol. The results of analysis were validated statistically and by recovery studies.
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